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Tuesday, May 6, 2014

Science Homework: Must-See Video (9:39): Wakefield's Smoking Gun, and a Reading List

From COncOrdance

May 5, 2014

Andrew Wakefield kicked off the modern anti-vaccine movement in 1998 with a publication in the Lancet linking autism to entercolitis (gut inflammation). He followed this with an expanded study in 2000, and evidence showing that measles replication in the gut was causing the inflammation in 2002.

The Lancet 1998 and American Journal of Gastroenterology 2000 papers were later retracted, at least in part because the samples used in those studies were obtained unethically and outside of ethical review of human research.

The Molecular Pathology 2002 paper was never retracted. The General Medical Council (UK) in their public hearings disclosed the raw data obtained during an investigation. It came to me through a colleague involved in the investigation and I want to share it with you. It is the smoking gun that convinced me that Wakefield was involved in an intentional fraud, that he was aware the data he was producing was false and deceptive.



Here are some links to learn more.

Investigator Brian Deer details the full chronology with essential primary documents. Excellent, thorough journalism: http://briandeer.com/mmr/lancet-summa...

The GMC findings in the case of Andrew Wakefield. It details the way Wakefield collected blood samples at his children's birthday parties, and the ethical violations. http://www.gmc-uk.org/Wakefield_SPM_a...

A brief introduction to real-time PCR:
http://pathmicro.med.sc.edu/pcr/realt...

The Three Papers Referenced

1.) Lancet. 1998 Feb 28;351(9103):637-41.
"Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children." [RETRACTED]

http://www.ncbi.nlm.nih.gov/pubmed/95...

2.) Am J Gastroenterol. 2000 Sep;95(9):2285-95.
"Enterocolitis in children with developmental disorders." [RETRACTED]

http://www.ncbi.nlm.nih.gov/pubmed/11...

3.) Mol Pathol. 2002 Apr;55(2):84-90.
"Potential viral pathogenic mechanism for new variant inflammatory bowel disease."
http://www.ncbi.nlm.nih.gov/pmc/artic...

......................................................................................

And, from the Blog "Harpocrates Speaks"...

More Recommended Reading on Andrew Wakefield 

ABC News - Doctor Who Claimed Vaccine-Autism Sues Critic
BMJ - Texas judge throws out Wakefield's libel action against BMJ
BMJ - Wakefield's article linking MMR vaccine and autism was fraudulent
Boing Boing - Read the journalism that exposed MMR vaccine/autism fraud
briandeer.com - Disgraced ex-doctor launches fourth attempt to gag media
CBS News - Dr. Sanjay Gupta Confronts Autism Study Doctor
CBS News - Measles uptick in Britain: Blame Andrew Wakefield's autism-vaccine study?
CNN - Retracted autism study an 'elaborate fraud,' British journal finds
Columbia Journalism Review - Sticking with the truth
The Daily Beast - MMR Vaccine Scare: Andrew Wakefield's Fraudulent Study
Forbes - Blame Wakefield for Missed Autism-Gut Connection
Forbes - Discredited Autism Researcher Chills Future Research
Forbes - Extradite Andrew Wakefield to Face Fraud Charges in the UK
The Guardian - Andrew Wakefield: autism inc
How Stuff Works - Andrew Wakefield's Autism-Vaccine Hoax
Immunization Action Coalition - The Fraud Behind the MMR Scare
Just the Vax - Wakefield Attempts (yet again) to Silence a Critic
Left Brain Right Brain - Andrew Wakefield takes to the courts again
Little Green Footballs - Wakefield's Anti-Vaccination Fraud: Smoking Gun
Los Angeles Times - Wakefield's paper linking MMR vaccine and autism a fraud on the scale of Piltdown man, BMJ editorial says
Mayo Clinic Proceedings - MMR Vaccine and Autism: Vaccine Nihilism and Postmodern Science
The New York Times - Autism Fraud
The New York Times - The Crash and Burn of an Autism Guru
The New York Times - Study Linking Vaccine to Autism Is Called Fraud
NPR - As the Facts Win Out, Vaccinations May, Too
Penumbrage - Is Andrew Wakefield a fraud and a bully?
Popehat - Andrew Wakefield Sues BMJ and Brian Deer: Time to Test Out the New Texas Anti-SLAPP Statute
The Poxes Blog - Andrew Jeremy Wakefield, Litigious Bully
Respectful Insolence - Legal thuggery, antivaccine edition: Andrew Wakefield sues Brian Deer, the BMJ, and Fiona Godlee
Respectful Insolence - "Piltdown" medicine: Andrew Wakefield's scientifice fraud was worse than previously thought
Retraction Watch - Some quick thoughts and links on Andrew Wakefield, the BMJ, autism, vaccines, and fraud
Science-based Medicine - Antivaccine hero Andrew Wakefield: Scientific fraud?
The Skeptic's Dictionary - Andrew Wakefield
The Skeptical Lawyer - Quickie News: Wakefield sues British authors and publishers for libel - in Texas
Skeptical Raptor - Andrew Wakefield sues BMJ for claiming MMR study was fraudulent
Time Magazine - Great Science Frauds: Andrew Wakefield
The Washington Times - Will autism fraud report be a vaccine booster?
WebMD - Autism/MMR Vaccine Study Faked: FAQ

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